Our lab studies the somatic evolution of the adaptive immune system to address crucial questions in cancer immunology and immune aging. In cancer, we seek to elucidate the timing and dynamics of the immune response to tumors, how chronic inflammation remodels the immune system to facilitate cancer progression, and the action of immunotherapies on T cell clonotypes. We aim to use these studies to enhance cancer treatment and patient outcomes. Our work on immune aging delves into the genomic and phenotypic characteristics of T cell immunosenescence and the implications for disease progression. By combining cutting-edge techniques in single-cell multiomics and phylogenetic lineage tracing, our research strives to understand how immune and non-immune cells co-evolve and contribute to cancer progression and aging.